Caffeine (data page)

This page provides supplementary chemical data on caffeine.

Caffeine
Hybrid skeletal structure of the caffeine molecule
Names
IUPAC names
1,3,7-Trimethyl-3,7-dihydro-1H-purine-2,6-dione
1,3,7-trimethyl-1H-purine-2,6(3H,7H)-dione
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
Caffeine
Identifiers
3D model (JSmol)
17705
ChEBI
ChEMBL
ChemSpider
DrugBank
EC Number
  • 200-362-1
103040
KEGG
RTECS number
  • EV6475000
UNII
  • InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 Y
    Key: RYYVLZVUVIJVGH-UHFFFAOYSA-N Y
  • InChI=1/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3
    Key: RYYVLZVUVIJVGH-UHFFFAOYAW
  • O=C2N(c1ncn(c1C(=O)N2C)C)C
  • Cn1cnc2c1c(=O)n(c(=O)n2C)C
Caffeine
Properties
C8H10N4O2
Molar mass 194.194 g·mol−1
Appearance Odorless, white needles or powder
Density 1.23 g/cm3, solid[1]
Melting point 227 to 228 °C (441 to 442 °F; 500 to 501 K) (anhydrous)
234 to 235 °C (453 to 455 °F; 507 to 508 K) (monohydrate)
Boiling point 178 °C (352 °F; 451 K) (sublimation)
2.17 g/100 mL (25 °C)
18.0 g/100 mL (80 °C)
67.0 g/100 mL (100 °C)
Acidity (pKa) −0.13–1.22[2]
3.64 D (calculated)
Caffeine
Hazards
GHS labelling:[3]
Warning
H302
P264, P270, P301+P312, P501
NFPA 704 (fire diamond)
2
0
0
Lethal dose or concentration (LD, LC):
192 mg/kg (rat, oral)[4]
Safety data sheet (SDS) ICSC 0405
  This box:   

References
  1. Caffeine, International Occupational Safety and Health Information Centre (CIS)
  2. This is the pKa for protonated caffeine, given as a range of values included in Harry G. Brittain, Richard J. Prankerd (2007). Profiles of Drug Substances, Excipients and Related Methodology, volume 33: Critical Compilation of pKa Values for Pharmaceutical Substances. Academic Press. ISBN 978-0-12-260833-9.
  3. Merck 102584
  4. Peters, Josef M. (1967). "Factors Affecting Caffeine Toxicity: A Review of the Literature". The Journal of Clinical Pharmacology and the Journal of New Drugs. 7 (3): 131–141. doi:10.1002/j.1552-4604.1967.tb00034.x. Archived from the original on 2008-06-10. Retrieved 2011-09-25.
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