DCHS2

DCHS2
Identifiers
Aliases	DCHS2, CDH27, CDHJ, CDHR7, PCDH23, PCDHJ, dachsous cadherin-related 2
External IDs	OMIM: 612486 HomoloGene: 130686 GeneCards: DCHS2
Gene location (Human)
Chr.	Chromosome 4 (human)[1]
End	154,491,799 bp[1]
RNA expression pattern
	Top expressed in
	kidney; ; prefrontal cortex; ; stomach; ; Achilles tendon; ; colon; ; sural nerve; ; superior frontal gyrus; ; caudate nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; molecular function; cadherin binding;
Cellular component	integral component of membrane; plasma membrane; membrane; cellular component;
Biological process	cell adhesion; homophilic cell adhesion via plasma membrane adhesion molecules; biological process; cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	54798
	n/a
	ENSG00000197410; ENSG00000284227
	n/a
	Q6V1P9
	n/a
	NM_001142552; NM_001142553; NM_017639; NM_199348; NM_001358235
	n/a
	NP_001136024; NP_001345164
	n/a
	Wikidata
View/Edit Human

Protein dachsous homolog 2, also known as protocadherin-23 (PCDH23) or cadherin-27 (CDH27), is a protein that in humans is encoded by the DCHS2 gene.[3][4]

DCHS2 has been implicated in the nose angle (how much a nose is upturned).[5] As well as facial genetics [6][7]

References

ENSG00000284227 GRCh38: Ensembl release 89: ENSG00000197410, ENSG00000284227 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: dachsous 2 (Drosophila)".
Höng JC, Ivanov NV, Hodor P, Xia M, Wei N, Blevins R, Gerhold D, Borodovsky M, Liu Y (March 2004). "Identification of new human cadherin genes using a combination of protein motif search and gene finding methods". J. Mol. Biol. 337 (2): 307–17. doi:10.1016/j.jmb.2004.01.026. PMID 15003449.
"A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation".
"Facial Genetics: a Brief Overview" (PDF).
"Your nose--Big or small--is shaped by your DNA".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.

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[refGRCh38Ensembl-1] ENSG00000284227 GRCh38: Ensembl release 89: ENSG00000197410, ENSG00000284227 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: dachsous 2 (Drosophila)".

[pmid15003449-4] Höng JC, Ivanov NV, Hodor P, Xia M, Wei N, Blevins R, Gerhold D, Borodovsky M, Liu Y (March 2004). "Identification of new human cadherin genes using a combination of protein motif search and gene finding methods". J. Mol. Biol. 337 (2): 307–17. doi:10.1016/j.jmb.2004.01.026. PMID 15003449.

[nose-angle-5] "A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation".

[facial-genetics-6] "Facial Genetics: a Brief Overview" (PDF).

[nose-big-small-7] "Your nose--Big or small--is shaped by your DNA".

DCHS2

References

Further reading