Dehydroaltenusin

Dehydroaltenusin is an inhibitor of mammalian DNA polymerase α.[1] It has been isolated from the fungus Alternaria tenuis.[1]

Dehydroaltenusin
Names
IUPAC name
3,7-Dihydroxy-9-methoxy-4a-methylbenzo[c]chromene-2,6-dione
Identifiers
3D model (JSmol)
ChemSpider
  • InChI=1S/C15H12O6/c1-15-6-12(18)10(16)5-9(15)8-3-7(20-2)4-11(17)13(8)14(19)21-15/h3-6,17-18H,1-2H3
    Key: YWYZLBQRCUAQAV-UHFFFAOYSA-N
  • InChI=1/C15H12O6/c1-15-6-12(18)10(16)5-9(15)8-3-7(20-2)4-11(17)13(8)14(19)21-15/h3-6,17-18H,1-2H3
    Key: YWYZLBQRCUAQAV-UHFFFAOYAK
  • CC12C=C(C(=O)C=C1C3=CC(=CC(=C3C(=O)O2)O)OC)O
Properties
C15H12O6
Molar mass 288.255 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

References
  1. Mizushina, Y; Maeda, N; Kuriyama, I; Yoshida, H (2011). "Dehydroaltenusin is a specific inhibitor of mammalian DNA polymerase α". Expert Opinion on Investigational Drugs. 20 (11): 1523–34. doi:10.1517/13543784.2011.619977. PMID 21923630. S2CID 207476077.


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