HFM1

HFM1
Identifiers
Aliases	HFM1, MER3, POF9, SEC63D1, Si-11, Si-11-6, helicase, ATP-dependent DNA helicase homolog, ATP dependent DNA helicase homolog, helicase for meiosis 1
External IDs	OMIM: 615684 MGI: 3036246 HomoloGene: 87103 GeneCards: HFM1
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	91,404,856 bp[1]
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)[2]
End	106,926,321 bp[2]
RNA expression pattern
	Top expressed in
	pituitary gland; ; anterior pituitary; ; heart; ; testicle; ; kidney; ; lung;
	More reference expression data
	n/a
Gene ontology
Molecular function	ATP binding; hydrolase activity; nucleotide binding; nucleic acid binding; GO:0008026 helicase activity;
Cellular component	nucleolus; cytoplasm;
Biological process	resolution of meiotic recombination intermediates; GO:0007126 meiosis; RNA secondary structure unwinding;
	Sources:Amigo / QuickGO
Orthologs
	164045
	330149
	ENSG00000162669
	ENSMUSG00000043410
	A2PYH4; C9JQ07
	D3Z4R1
	NM_001017975
	NM_001252516; NM_177873
	NP_001017975
	NP_001239445; NP_808541
	Wikidata
View/Edit Human	View/Edit Mouse

HFM1 is a gene that in humans encodes a protein necessary for homologous recombination of chromosomes.[5] Biallelic mutations in HFM1 cause recessive primary ovarian insufficiency.[5]

References

GRCh38: Ensembl release 89: ENSG00000162669 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000043410 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Wang J, Zhang W, Jiang H, Wu BL (March 2014). "Mutations in HFM1 in recessive primary ovarian insufficiency". The New England Journal of Medicine. 370 (10): 972–4. doi:10.1056/NEJMc1310150. PMID 24597873.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000162669 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000043410 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[WangZhang2014-5] Wang J, Zhang W, Jiang H, Wu BL (March 2014). "Mutations in HFM1 in recessive primary ovarian insufficiency". The New England Journal of Medicine. 370 (10): 972–4. doi:10.1056/NEJMc1310150. PMID 24597873.