Interferon gamma 5' UTR regulatory element
Interferon gamma 5' UTR regulatory elements are a family of regulatory RNAs. This family represents a pseudoknot containing stem-loop structure found in the 5' UTR of interferon-gamma mRNA. This structure is thought to be involved in translational regulation and the pseudoknot has been found to activate protein kinase R (PKR) which is known to be a translational inhibitor. Mutations in the pseudoknot structure have been found to reduce PKR activation and increase the translation of interferon-gamma.[1]
| Interferon gamma 5' UTR regulatory element | |
|---|---|
 Predicted secondary structure and sequence conservation of IFN_gamma | |
| Identifiers | |
| Symbol | IFN_gamma |
| Rfam | RF00259 |
| Other data | |
| RNA type | Cis-reg |
| Domain(s) | Eukaryota |
| SO | SO:0000204 |
| PDB structures | PDBe |
References
- Ben-Asouli Y, Banai Y, Pel-Or Y, Shir A, Kaempfer R (January 2002). "Human interferon-gamma mRNA autoregulates its translation through a pseudoknot that activates the interferon-inducible protein kinase PKR". Cell. 108 (2): 221–232. doi:10.1016/S0092-8674(02)00616-5. PMID 11832212.
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