LEKTI-2
Lympho-epithelial Kazal-type related inhibitor 2 (LEKTI-2) is a protein encoded by the SPINK9 gene in humans. LEKTI-2 is an inhibitor of KLK5, a serine protease expressed in the epidermis and responsible for coordinating skin homeostasis and desquamation. SPINK9 is a member of a gene family cluster located on chromosome 5q33.1, which includes SPINK5 and SPINK6.[3]
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| Aliases | SPINK9, LEKTI2, serine peptidase inhibitor, Kazal type 9, serine peptidase inhibitor Kazal type 9 | ||||||||||||||||||||||||
| External IDs | OMIM: 613511 HomoloGene: 88638 GeneCards: SPINK9 | ||||||||||||||||||||||||
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| Species | Human | Mouse | |||||||||||||||||||||||
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| Location (UCSC) | Chr 5: 148.32 – 148.34 Mb | n/a | |||||||||||||||||||||||
| PubMed search | [2] | n/a | |||||||||||||||||||||||
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References
- GRCh38: Ensembl release 89: ENSG00000204909 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Furio L, Hovnanian A. (November 2011). "When Activity Requires Breaking Up: LEKTI Proteolytic Activation Cascade for Specific Proteinase Inhibition". J Invest Dermatol. 131 (11): 2169–73. doi:10.1038/jid.2011.295. PMID 21997416.
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