Effective renal plasma flow

Effective renal plasma flow (eRPF) is a measure used in renal physiology[1] to calculate renal plasma flow (RPF) and hence estimate renal function. The eRPF can be calculated with

"eRPF" redirects here. For the river in Baden-Württemberg, Germany, see Erpf (river).
Parameter Value
renal blood flow RBF = 1000 mL/min
hematocrit HCT = 40%
glomerular filtration rate GFR = 120 mL/min
renal plasma flow RPF = 600 mL/min
filtration fraction FF = 20%
urine flow rate V = 1 mL/min
Sodium Inulin Creatinine PAH
SNa = 150 mEq/L SIn = 1 mg/mL SCr = 0.01 mg/mL SPAH =
UNa = 710 mEq/L UIn = 150 mg/mL UCr = 1.25 mg/mL UPAH =
CNa = 5 mL/min CIn = 150 mL/min CCr = 125 mL/min CPAH = 420 mL/min
ER = 90%
ERPF = 540 mL/min

where extraction ratio is the ratio of compound entering the kidney that is excreted into the final urine.[2]

When using a compound with an extraction ratio near 1, such as para-aminohippurate (PAH), eRPF approximates RPF. Therefore, PAH clearance can be used to estimate RPF.[3]

References
  1. "Hubio562: Clearance Lab Answers". Archived from the original on September 12, 2006. Retrieved 2009-04-29.
  2. Barrett, Kim E.; Brooks, Heddwen L.; Boitano, Scott; Barman, Susan M. (2010). Ganong's Review of Medical Physiology (23rd ed.). McGraw-Hill Medical. pp. 643–644. ISBN 978-0-07-160568-7. OCLC 430823856.
  3. Costanzo, Linda (2012). Physiology Cases and Problems. Lippincott Williams & Wilkins. p. 165. ISBN 9781451120615. Retrieved 1 November 2018.
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