Small nucleolar RNA SNORD14

In molecular biology, U14 small nucleolar RNA (U14 snoRNA) is a non-coding RNA required for early cleavages of eukaryotic precursor rRNAs. In yeasts, this molecule possess a stem-loop region (known as the Y-domain) which is essential for function. A similar structure, but with a different consensus sequence, is found in plants, but is absent in vertebrates.[1] In human there are two closely related copies called SNORD14A and SNORD14B that are expressed from the intron of their host gene ribosomal protein Rps13.

Small nucleolar RNA SNORD14
Predicted secondary structure and sequence conservation of SNORD14
Identifiers
SymbolSNORD14
Alt. SymbolsU14
RfamRF00016
Other data
RNA typeGene; snRNA; snoRNA; CD-box
Domain(s)Eukaryota
GOGO:0006396 GO:0005730
SOSO:0000593
PDB structuresPDBe

References
  1. Samarsky DA, Schneider GS, Fournier MJ (June 1996). "An essential domain in Saccharomyces cerevisiae U14 snoRNA is absent in vertebrates, but conserved in other yeasts". Nucleic Acids Research. 24 (11): 2059–66. doi:10.1093/nar/24.11.2059. PMC 145897. PMID 8668536.
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