Guacetisal

Guacetisal
Clinical data
Trade names	Broncaspin; Balsacetil; Guaiaspir; Prontomucil
Other names	Aspirin guaiacol ester; O-Methoxyphenyl salicylate acetate
ATC code	N02BA14 (WHO) ;
Identifiers
	IUPAC name 2-Methoxyphenyl 2-acetoxybenzoate;
CAS Number	55482-89-8;
PubChem CID	68749;
ChemSpider	61994;
UNII	T6EKB9V2O2;
ChEMBL	ChEMBL2105097;
CompTox Dashboard (EPA)	DTXSID40204060 ;
ECHA InfoCard	100.054.221
Chemical and physical data
Formula	C16H14O5
Molar mass	286.283 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	72 to 74.5 °C (161.6 to 166.1 °F)
	SMILES O=C(Oc1ccccc1C(=O)Oc2ccccc2OC)C;
	InChI InChI=1S/C16H14O5/c1-11(17)20-13-8-4-3-7-12(13)16(18)21-15-10-6-5-9-14(15)19-2/h3-10H,1-2H3; Key:HSJFYRYGGKLQBT-UHFFFAOYSA-N;

Guacetisal is a drug that has been used to treat inflammatory respiratory diseases.[1] Chemically, it is an ester resulting from the combination of aspirin and guaiacol.

References

Vizioli A, Zamperini D, Ursaia G (December 1982). "[Clinical trial of guacetisal in aged subjects with inflammatory diseases of the respiratory tract]". La Clinica Terapeutica. 103 (5): 527–33. PMID 6761043.

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[1] Vizioli A, Zamperini D, Ursaia G (December 1982). "[Clinical trial of guacetisal in aged subjects with inflammatory diseases of the respiratory tract]". La Clinica Terapeutica. 103 (5): 527–33. PMID 6761043.

Non-steroidal anti-inflammatory drugs (NSAIDs) (primarily M01A and M02A, also N02BA)
pyrazolones / pyrazolidines	Aminophenazone Ampyrone Azapropazone Clofezone Difenamizole Famprofazone Feprazone Kebuzone Metamizole Mofebutazone Morazone Nifenazone Oxyphenbutazone Phenazone Phenylbutazone Propyphenazone Sulfinpyrazone Suxibuzone^‡
salicylates	Aspirin (acetylsalicylic acid)^# Aloxiprin Benorylate Carbasalate calcium Diflunisal Dipyrocetyl Ethenzamide Guacetisal Magnesium salicylate Methyl salicylate Salsalate Salicin Salicylamide Salicylic acid (salicylate) Sodium salicylate
acetic acid derivatives and related substances	Aceclofenac Acemetacin Alclofenac Amfenac Bendazac Bromfenac Bufexamac Bumadizone Diclofenac Difenpiramide Etodolac Felbinac Fenclozic acid Fentiazac Indometacin Indometacin farnesil Isoxepac Ketorolac Lonazolac Mofezolac Oxametacin Prodolic acid Proglumetacin Sulindac Tiopinac Tolmetin Zomepirac^†
oxicams	Ampiroxicam Droxicam Isoxicam Lornoxicam Meloxicam Piroxicam Pivoxicam Tenoxicam
propionic acid derivatives (profens)	Alminoprofen Benoxaprofen^† Carprofen^‡ Dexibuprofen Dexketoprofen Fenbufen Fenoprofen Flunoxaprofen Flurbiprofen Ibuprofen^# Ibuproxam Indoprofen^† Ketoprofen Loxoprofen Miroprofen Naproxen Oxaprozin Piketoprofen Pirprofen Suprofen Tarenflurbil Tepoxalin^‡ Tiaprofenic acid Vedaprofen^‡ Zaltoprofen COX-inhibiting nitric oxide donator: Naproxcinod
n-arylanthranilic acids (fenamates)	Azapropazone Clonixin Etofenamate Floctafenine Flufenamic acid Flunixin Flutiazin Glafenine^† Meclofenamic acid Mefenamic acid Morniflumate Niflumic acid Tolfenamic acid
COX-2 inhibitors (coxibs)	Apricoxib Celecoxib (+tramadol) Cimicoxib^‡ Deracoxib^‡ Etoricoxib Firocoxib^‡ Lumiracoxib^† Mavacoxib^‡ Parecoxib Robenacoxib^‡ Rofecoxib^† Valdecoxib^†
other	Aminopropionitrile Benzydamine Chondroitin sulfate Diacerein Fluproquazone Glucosamine Glycosaminoglycan Hyperforin Nabumetone Nimesulide Oxaceprol Proquazone Superoxide dismutase / orgotein Tenidap
NSAID combinations	Ibuprofen/famotidine Ibuprofen/hydrocodone Ibuprofen/oxycodone Ibuprofen/paracetamol Meloxicam/bupivacaine Naproxen/diphenhydramine Naproxen/esomeprazole
Key: underline indicates initially developed first-in-class compound of specific group; ^#WHO-Essential Medicines; ^†withdrawn drugs; ^‡veterinary use.
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